LDLR抗体
Applications
| In-house applications |
ELISA, WB, IHC, IP, FC Application not tested? Please see our Guarantee. |
| Published applications |
WB |
Publications |
7 citations –view here |
| Species specificity |
Human, Mouse; other species not tested. |
| Published Species |
Chicken, Hamster, human, mouse |
|
Images
Prev12Next
 mouse brain tissue were subjected to SDS PAGE followed by western blot with 10785-1-AP(LDLR antibody) at dilution of 1:300 Immunohistochemical of paraffin-embedded human colon cancer using 10785-1-AP(LDLR antibody) at dilution of 1:50 (under 10x lens) Immunohistochemical of paraffin-embedded human colon cancer using 10785-1-AP(LDLR antibody) at dilution of 1:50 (under 40x lens) IP Result of anti-LDLR (IP:10785-1-AP, 5ug; Detection:10785-1-AP 1:500) with HeLa cells lysate 1200ug. 1X10^6 HeLa cells were stained with .2ug LDLR antibody (10785-1-AP, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1500.
|
| Positive WB detected in |
Mouse brain tissue, HeLa cells, HL-60 cells, human brain tissue, Jurkat cells, NIH/3T3 cells, Raji cells |
| Positive IP detected in |
HeLa cells |
| Positive IHC detected in |
Human colon cancer tissue, human brain tissue, human pancreas tissue |
| Positive FC detected in |
HeLa cells |
| Recommended dilution |
WB : 1:200-1:2000
IP : 1:200-1:2000
IHC : 1:50-1:200 |
LDLR抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
| Source |
Rabbit |
Purification method |
Antigen affinity purification |
| Isotype |
IgG |
Storage |
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information LDLR抗体
| Immunogen |
LDLR fusion protein ag1236 |
Full name |
Low density lipoprotein receptor |
Calculated molecular
weight |
95 kDa |
Observed molecular
weight |
150-160 kDa |
GenBank accession
number |
BC014514 |
Gene ID (NCBI) |
3949 |
| Gene symbol |
LDLR |
Synonyms |
FH, FHC, LDL receptor, LDLR |
Background
|
LDLR (low density lipoprotein receptor) is a member of the LDL receptor gene family and is involved in receptor-mediated endocytosis of specific ligands. The LDLR is a cell surface glycoproteins that scavenge LDL from the blood and regulate plasma LDL cholesterol. The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits, which promotes the rapid endocytosis of bound LDL. The protein is highly glycosylated through N- and O-linkages and thus migrates at 100 to 160 kDa bands on SDS-PAGE. LDLR抗体
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