APC 抗体
Applications
| Tested Applications: |
ELISA, IHC |
| Specificity Reaction: |
Human,Mouse,Rat; Other species are not tested.Please decide the specificity by homology |
| Positive IHC detected in |
Human breast cancer tissue, human colon cancer tissue, human colon tissue, human endometrial cancer tissue |
| ApplicationNote: |
This antibody is recommended for IHC test. |
| Recommended dilution |
IHC : 1:20-1:200 |
Application key: WB=Western Blotting ,IHC=Immunohistochemistry, IF=Immunofluorescence
Images
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Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 19782-1-AP( APC Antibody) at dilution of 1:50. Heat mediated antigen retrieved with Citric acid buffer, pH6.0.
Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 19782-1-AP (APC Antibody) at dilution of 1:50. Heat mediated antigen retrieved with Citric acid buffer, pH6.0.
Product Information
| Source: |
Rabbit |
Purify: |
Antigen affinity purification |
| IsoType: |
IgG |
Storage: |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles. |
Immunogen Information APC 抗体
| Immunogen: |
Peptide |
Full Name: |
Adenomatous polyposis coli |
Caculated Molecular
Weight: |
312 kDa |
Observed Molecular
Weight: |
|
| GenbankNo |
NM_000038 |
GeneID: |
324 |
| Symbol |
APC |
Synonyms |
Adenomatous polyposis coli, APC, BTPS2, Deleted in polyposis 2.5, DP2, DP2.5, DP3, GS, Protein APC |
Background APC 抗体
|
APC, also named as DP2.5, belongs to the adenomatous polyposis coli (APC) family. APC is a tumor suppressor that regulates cell division, helps ensure that the number of chromosomes in a cell is correct following cell division, and associates with other proteins involved in cell attachment and signaling. APC promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. It plays a critical role in several cellular processes. APC regulates beta-catenin levels through Wnt-signaling and is involved in actin cytoskeletal integrity, cell-cell adhesion and cell migration. APC activity is correlated with its phosphorylation state. Defects in APC are a cause of familial adenomatous polyposis (FAP) which includes also Gardner syndrome (GS). Defects in APC are a cause of hereditary desmoid disease (HDD) which also known as familial infiltrative fibromatosis (FIF). Defects in APC are a cause of medulloblastoma (MDB) which is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. Defects in APC are a cause of mismatch repair cancer syndrome (MMRCS) which also known as Turcot syndrome or brain tumor-polyposis syndrome 1 (BTPS1). APC 抗体
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